After a business trip to Macao, businesswoman Beth Emhoff (Gwyneth Paltrow) stops in Chicago to have a sexual encounter with an old boyfriend before returning to her family in suburban Minneapolis. At first, she appears to have contracted a cold during her trip. Her son, Clark, also becomes symptomatic and is sent home from school. Beth's condition worsens and two days later she collapses with severe seizures in her home. Her husband, Mitch (Matt Damon), rushes her to the hospital, but she continues to have seizures and dies of an unknown cause. Because it affects the brain and central nervous system, pathologists attribute it to a meningoencephalitis virus. Mitch returns home and finds that Clark has also died from a similar infection. Mitch is put in isolation but turns out to be immune to the disease. He and his teenaged daughter attempt to flee the city, but a military quarantine has been imposed, and they're forced to return to their home to face decaying social order and rampant looting of stores and homes. Not knowing whether his daughter inherited his immunity, Mitch struggles to her frustration with quarantine with his desire to protect her, while trying to come to terms with his own loss. watch more

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