Soderbergh and screenwriter Scott Z. Burns had collaborated on The Informant! (2009). Following that film's release, the two considered creating a biopic covering Leni Riefenstahl's life before Burns brought up the idea of producing a medical thriller film depicting a virus's rapid spread, which was inspired by various pandemics such as the 2003 SARS epidemic and the 2009 flu pandemic. To devise an accurate perception of a pandemic event, Burns consulted with representatives of the World Health Organization as well as renowned medical personnel such as W. Ian Lipkin and Lawrence "Larry" Brilliant. Principal photography started in Hong Kong in September, and continued in Chicago, Atlanta, London, Geneva, and San Francisco until February 2011.
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